A Relative Bioavailability Study of Two Misoprostol Formulations Following a Single Oral or Sublingual Administration
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چکیده
منابع مشابه
Pharmacokinetics and Bioavailability Comparison of two oral Tablet Formulations of Escitalopram 20 mg: A Single-Dose, Open-Label, Two-Period Crossover Study in Healthy Indian Adult Subjects
This study was done to assess bioequivalence between test and reference formulations of escitalopram oxalate 20 mg in healthy Indian male subjects. This single-dose, randomized, open-label, 2-period crossover study was carried out in 12 Healthy Indian Male volunteers aged 18 to 55 years under fasting conditions with a wash out of 14 days. The subjects were randomly assigned to receive the test...
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متن کاملHigh fever following postpartum administration of sublingual misoprostol
OBJECTIVE To explore what triggers an elevated body temperature of > or =40.0 degrees C in some women given misoprostol, a prostaglandin E1 analogue, for postpartum haemorrhage (PPH). DESIGN Post hoc analysis. SETTING One tertiary-level hospital in Quito, Ecuador. POPULATION A cohort of 58 women with a fever of above 40 degrees C following treatment with sublingual misoprostol (800 microg...
متن کاملComparison of misoprostol plasma concentrations following buccal and sublingual administration.
BACKGROUND New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal. MATERIALS AND METHODS This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs. sublingual m...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2020
ISSN: 1663-9812
DOI: 10.3389/fphar.2020.00050